National Cheeseburger Day, a Vancouver, Washington location that ran out of buns, lettuce, and pickles by six, and a two-hour wait made bearable by free peanuts and better company than expected — plus where this one lands against In-N-Out and Habit.
Three weeks after approving daraxonrasib for pancreatic cancer that has already been treated — the first drug to roughly double survival in that disease — the FDA gave it Breakthrough Therapy status for newly diagnosed patients, on top of chemotherapy. What the drug does, what the trials actually sh
My friend sent a screenshot of the XRP rich list and a thought: only 8.13 million XRP accounts exist, so "less than 1 percent of 1 percent" of humanity owns any, and yet the coin gets endless attention. Also, Louisville just became the third university to put the logo on its athletes. He's right abo
The same friend who has kept this week's entries honest sent two more texts tonight — three Ripple links, a line about how "AI and crypto will merge," and a theory involving Elon Musk's favorite letter and a 2 percent stake Stripe took in 2014. I read all three announcements. He's right that the pip
A post went around this week saying Zcash at $1,200 is Bitcoin at $1,200 — study 2017. The arithmetic behind it is genuinely correct, which is the most interesting thing about it and the reason it's worth taking apart. Here is what the post is actually claiming, why the supply math works, why the co
A bed net costs about $6 and lasts three years, which makes malaria prevention a subscription with 600 million subscribers and no end date. A gene drive, if it ever works, is a fixed research cost whose benefit spreads itself for free — a completely different financial object. Global malaria funding
The same morning the SEC gave tokenized stocks a five-year exemption, the CFTC's staff quietly did something with a longer shelf life and a smaller signature: a seven-page letter saying any app that routes orders to a registered exchange, holds none of the money, and takes a cut of every trade doesn
Yesterday I wrote that the SEC and CFTC would build crypto rules without Congress. This morning the same friend who started that conversation texted me the SEC's "Innovation Exemption" with two words of commentary — "the genie" — and a five-year number. He's right about the number. Here's what the o
Malaria killed about 610,000 people in 2024, three quarters of them children under five. One approach to ending it does not spray anything, distribute anything, or ask anyone to take a pill — it edits the mosquito so the parasite cannot survive inside it, and lets the edit spread itself through the
Ursula von der Leyen's 2026 State of the Union names a war on the continent, a closed Strait of Hormuz that has cost Europe €90 billion, a €1-billion-a-day trade deficit with China and a Russian drone attack in Leipzig — and the two proposals that leave the hall with a date attached are a Heatwave P
On September 14 the FDA approved Bexlutry, Curium's copy of Novartis's Lutathera — the first "radioligand equivalent" ever cleared. The question underneath the headline: what is a radioligand therapy, what does the evidence say it does for neuroendocrine tumours, and why did it take a Delaware court
A friend forwarded me a tweet the morning after the CLARITY Act's cloture vote failed — a former CFTC chairman saying the current SEC and CFTC chiefs will build crypto rules with or without Congress. It reads like a hypothetical. It isn't. Both agencies have been building exactly that framework in p
The Fed hiked a quarter point on Wednesday, 12 to 0 — unanimous, from a committee that voted 9 to 3 to hold in July. Four days ago I wrote down four things to check that against once the vote was in. Here is what actually happened to each one.
A friend sent me a screenshot of a "Total RWA Value" chart at $57.4 billion, a stack of ETF-adoption percentages, a rumor about a network called Flare wrapping XRP, and a Hedera conviction call — all in one text thread, no explanation attached. So I went and found out what each piece actually is: wh
A video making the rounds walks through a real trend — stock exchanges tokenizing shares — then pivots to Basel I, II and III, and lands on a specific claim: the newest paper out of Basel mentions XRP dozens of times, therefore the Bank for International Settlements is about to use it. The paper is
The Senate held a cloture vote today on the CLARITY Act, the bill meant to finally tell crypto exchanges which regulator they answer to. Forty-nine senators voted yes, fifty voted no, and the rule requires sixty. Bitcoin slid through the session as the vote failed. Here is what the bill would have d
A real mining-hardware company tweeted this week that it built a Bitcoin miner out of a fruit fly's brain, claiming ten times the efficiency of the best silicon ASIC on the market. The neuron map behind it is genuinely new science, released this month. The miner is one tweet, no paper, no repository
Costco started rationing motor oil this week, a first in its history — two boxes of its own Kirkland Signature synthetic per member, per week. Tracing the four steps between a closed pipeline in the Saudi desert and a purchase limit at a warehouse club also half-answers the question the last two ent
A phone-forensics demonstration circulating on X this week is a reminder that "only law enforcement has this" was never really the boundary — the tools, the vendors and the exploits all move. What a locked iPhone actually protects, what Advanced Data Protection does and doesn't cover, and a short hi
On Friday the inflation number came in at 3.4 percent and the futures market moved to better than 85 percent odds that the Federal Reserve raises interest rates next Wednesday. Take energy out of that 3.4 and it reads 2.4 — a whisker from the target. So the Fed is about to raise the price of money i
Between July 2021 and April 2023 the Antarctic ice sheet got heavier by about 695 billion tons — the largest gain in the twenty-four-year satellite-gravity record. A paper in Nature traces it to a warm patch of tropical ocean that bent the atmosphere over East Antarctica and turned it into a snow fu
On 3 September the BepiColombo spacecraft, two hundred million kilometres from Earth, let go of the engine that carried it for eight years and 9.9 billion kilometres. On 21 November it has to stop at Mercury, the hardest planet in the solar system to arrive at, using a sequence it will run on its ow