original antigenic sin
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original antigenic sin
Where it comes from
See original sin.
noun
-
The propensity of the immune system to preferentially use immunological memory based on a previous infection when a second, slightly different version of the foreign pathogen is encountered, leaving the immune system "trapped" by the first response it has made to each antigen, and unable to mount potentially more effective responses during subsequent infections.
Similar: Hoskins effect, OAS
Talk about this word "original antigenic sin." Wiktionary, via Micwyn, micwyn.com/word/original%20antigenic%20sin. Accessed 6 Nov. 2026. original antigenic sin. (n.d.). In Wiktionary, via Micwyn. Retrieved November 6, 2026, from https://micwyn.com/word/original%20antigenic%20sin "original antigenic sin." Wiktionary, via Micwyn. Accessed November 6, 2026. https://micwyn.com/word/original%20antigenic%20sin.Cite this
@misc{original_antigenic_sin_2026,
title = {original antigenic sin},
howpublished = {Wiktionary, via Micwyn},
year = {2026},
url = {https://micwyn.com/word/original%20antigenic%20sin},
urldate = {2026-11-06}
}
