antagonist

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antagonist

  • /ænˈtæɡənɪst/ UK
  • /ænˈtæɡənɪst/ Canada, US
  • [ɛə̯nˈtæɡənɪst] Canada, US
  • /ænˈtæɡənɪst/ Australia

Where it comes from

From Latin antagonista, from Ancient Greek ἀνταγωνιστής (antagōnistḗs, “opponent”) (ἀντί (antí, “against”) + ἀγωνιστής (agōnistḗs, “a combatant, pleader, actor”)), from ἀνταγωνίζομαι (antagōnízomai, “to antagonize”).

noun antagonists

  1. An opponent or enemy. our antagonists in these controversies
  2. One who antagonizes or stirs.
  3. A chemical that binds to a receptor but does not produce a physiological response, blocking the action of other agonist chemicals, such as endogenous chemical messengers. 2001: The calcium antagonists represent one of the top ten classes of prescription drugs in terms of commercial value, with worldwide sales of nearly $10 billion in 1999. — Leslie Iversen, Drugs: A Very Short Introduction (Oxford 2001, p. 41)

    Similar: blocker

  4. The main character or force opposing the protagonist in a literary work or drama. So God forbid I'm seen just as an average human being / I mean, imagine if antagonists lacked any evil scheme
  5. A muscle that acts in opposition to another. A flexor, which bends a part, is the antagonist of an extensor, which extends it.

Opposite: protagonist, agonist

Thesaurus

Closest in meaning: adversary, opponent, adversarial, antagonistic, foe, conflicting, opposing, confrontational, phentolamine, saralasin, propranolol, prazosin, bicuculline, cimetidine, yohimbine, rival

noun

Opposite: protagonist, agonist

Translations

Every language

noun opponent

Españolantagonista
中文對手 /对手 duìshǒu, 敵手 /敌手 díshǒu
हिन्दीशत्रु śatru, विरोधी virodhī
Portuguêsantagonista
Françaisantagoniste
DeutschAntagonist, Widersacher, Gegner
Italianoantagonista
Ελληνικάανταγωνιστής antagonistís
Românăantagonist, oponent
Русскийантагони́ст antagoníst
العربيةخَصْم ḵaṣm, عَدُوّ ʕaduww

noun one who antagonizes

Españolantagonista
Portuguêsantagonista
Italianooppositore, avversario, concorrente
Ελληνικάανταγωνιστής antagonistís
Русскийантагони́ст antagoníst

noun chemical

中文拮抗劑 /拮抗剂 jiékàngjì
Portuguêsantagonista
DeutschAntagonist
Italianoantagonista
Ελληνικάανταγωνιστής antagonistís

noun main character or force opposing the protagonist

日本語敵役
Françaisantagoniste
DeutschAntagonist
Românăantagonist
العربيةغَرِيم ḡarīm, خَصْم ḵaṣm, شِرِّير širrīr

noun muscle

中文拮抗肌 jiékàngjī

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Cite this
MLA

"antagonist." Wiktionary, via Micwyn, micwyn.com/word/antagonist. Accessed 6 Nov. 2026.

APA

antagonist. (n.d.). In Wiktionary, via Micwyn. Retrieved November 6, 2026, from https://micwyn.com/word/antagonist

Chicago

"antagonist." Wiktionary, via Micwyn. Accessed November 6, 2026. https://micwyn.com/word/antagonist.

BibTeX
@misc{antagonist_2026,
  title = {antagonist},
  howpublished = {Wiktionary, via Micwyn},
  year = {2026},
  url = {https://micwyn.com/word/antagonist},
  urldate = {2026-11-06}
}